Search results for "IgG4-related disease"

showing 4 items of 4 documents

T cell Polarization toward T(H)2/T(FH)2 and T(H)17/T(FH)17 in Patients with IgG4-related Disease

2017

International audience; IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder involving virtually every organ with a risk of organ dysfunction. Despite recent studies regarding B cell and T cell compartments, the disease's pathophysiology remains poorly understood. We examined and characterized subsets of circulating lymphocytes in untreated patients with active IgG4-RD. Twenty-eight consecutive patients with biopsy-proven IgG4-RD were included in a prospective, multicentric study. Lymphocyte's subsets were analyzed by flow cytometry, with analysis of T(H)1/T(H)2/T(H)17, T-FH cells, and cytokine release by peripheral blood mononuclear cells. Results were compared to healthy contro…

0301 basic medicinemedicine.medical_treatmentT cellImmunologyplasmablastsBiologyCXCR3Peripheral blood mononuclear cellFlow cytometry03 medical and health sciencesInterleukin 21T helper cellsmedicineImmunology and AllergyCytotoxic T cellIgG4-related diseaseB cellmedicine.diagnostic_test3. Good health030104 developmental biologyCytokinemedicine.anatomical_structureSjögren’s syndromeImmunologyT follicular helper cells[SDV.IMM]Life Sciences [q-bio]/Immunology
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Ophthalmic manifestations in IgG4-related disease

2017

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AdultAged 80 and overMaleEye Diseases3600Anti-Inflammatory AgentsObservational StudyMiddle AgedEyeYoung AdultrituximabImmune System DiseasesImmunoglobulin GComputingMethodologies_DOCUMENTANDTEXTPROCESSINGHumansPrednisoneFemaleIgG4-related diseaseorbital inflammatory pseudo-tumorIgG4-related dacryoadenitisIgG4-related ophthalmic diseaseResearch ArticleAgedRetrospective StudiesMedicine
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IgG4 Related Syndrome: Another Multiorgan Disease in the Interest Field of Internal Medicine.

2016

BACKGROUND: IgG4-related disease is a rare, clinical and pathologic disease entity of unknown etiology. Its main features are increased serum concentrations of IgG4 > 1,35 g/l, lymphocyte and IgG4+plasma-cell infiltration within tissues, fibrosis or sclerosis. The classical presentation of IgG4-RSD is pancreatitis which is combined with the involvement of biliary ducts in 74 percent of patients. Extrapancreatic manifestations include: abdominal or mediastinal lymphadenopathy; the involvement of salivary glands and lacrimal glands, kidneys, lung, retroperitoneum. Since IgG4-related disease is a multiorgan lymphoproliferative syndrome, it requires a careful differential diagnosis from othe…

MaleSystemic diseasePathologymedicine.medical_specialtySettore MED/09 - Medicina InternaCholangitis SclerosingLymphadenopathyAzathioprineRetroperitoneal fibrosisSialadenitisIgG4 syndrome Internal MedicineDrug DiscoveryInternal MedicinemedicineHumansEosinophiliaAgedPharmacologybusiness.industryRetroperitoneal FibrosisSyndromemedicine.diseaseImmunoglobulin GPancreatitisIgG4-related diseaseSarcoidosismedicine.symptomDifferential diagnosisbusinessmedicine.drug
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T Cell Polarization toward T

2016

IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder involving virtually every organ with a risk of organ dysfunction. Despite recent studies regarding B cell and T cell compartments, the disease’s pathophysiology remains poorly understood. We examined and characterized subsets of circulating lymphocytes in untreated patients with active IgG4-RD. Twenty-eight consecutive patients with biopsy-proven IgG4-RD were included in a prospective, multicentric study. Lymphocytes’ subsets were analyzed by flow cytometry, with analysis of TH1/TH2/TH17, TFH cells, and cytokine release by peripheral blood mononuclear cells. Results were compared to healthy controls and to patients with primary…

T helper cellsSjögren’s syndromeImmunologyT follicular helper cellsplasmablastsIgG4-related diseaseOriginal ResearchFrontiers in immunology
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